Posted by - Formal Title: Recombination Signal Sequences providing evidence for low vitality cerebral output in higher order Apes when compared with ancient Transibs
The V(D)J recombination reaction in jawed vertebrates is catalyzed by the RAG1 and RAG2 proteins, which are believed to have emerged approximately 500 million years ago from transposon-encoded proteins. What makes this extremely interesting is that no transposase sequence similar to RAG1 or RAG2 has been found (yet). What is evident is that the approximately 600-amino acid “core” region of RAG1 required for its catalytic activity is significantly similar to the transposase encoded by DNA transposons that belong to the Transib superfamily. This superfamily was discovered recently based on computational analysis of the fruit fly and African malaria mosquito genomes. Transib transposons also are present in the genomes of sea urchin, yellow fever mosquito, silkworm, dog hookworm, hydra, and soybean rust. By demonstrating that recombination signal sequences (RSSs) were derived from terminal inverted repeats of an ancient Transib transposon, I was able to prove critical adaptation exists and the common ancestral latencies related to an above average (longitudinal) evolutionary niche when compared against the average, modern-day Homo Sapien (ref. higher order Apes). This presents as central doctrine to the represented hypothesis of the majority remaining unburdened by substantial energy requirements of quartile II and III cerebral activity. Furthermore, the critical DDE catalytic triad of RAG1 is shared with the Transib transposase as part of conserved motifs. Additionally, several divergent proteins encoded by the sea urchin and lancelet genomes that are 25%−30% identical to the RAG1 N-terminal domain and the RAG1 core were compared with my human control group. My results provide the first direct evidence linking RAG1 and RSSs to a specific superfamily of DNA transposons and indicate that the V(D)J machinery evolved from transposons. As a result, I propose that only the RAG1 core was derived from the Transib transposase, whereas the N-terminal domain was assembled from separate proteins of unknown function that may still be active in sea urchin, lancelet, hydra, and starlet sea anemone. Logically, this also suggests that the RAG2 protein was not encoded by ancient Transib transposons but emerged in jawed vertebrates as a counterpart of RAG1 necessary for the V(D)J recombination reaction and therefore is indicative of a more superior genetic structure than in what was viewed from the lower-cerebral compensatory behaviors of the (theoretically) neocortex-enhanced bipedal apes.
In summation, ancient invertebrates were actually smarter than you. Have a splendid weekend. Go forth and multiply.
I can see where you are going here. Have you considered the works of Theodor Geisel – he spoke much on this subject siting various examples – one I can recall was the W.H.O. population and their striking, almost clone-like, resemblances.
I’ll grant you this is the first time I’ve seen the RAG1 core linked to the transposons you suggest, but the general idea is hardly new. Peter Schechter suggested that V(D)J transdurial etachrons were most likely transposon-derivative. I actually heard him deliver that paper, and that was in 1998, and he mentioned the work of Hawley and Nerr-Jenkins which nearly predated him by ten years, although, IIRC, they had actually worked more down the path of piezoelectric protein uratosis due to the decay of ectoposons, rather than transposons.
Anyway, not minimizing your idea by any stretch, but we should acknowledge we stand on the shoulders of giants, here.
Hmmm… although I take issue with the direct implication of the research lacking novelty, I will commend you on your attribution chain. However, some minor corrections are most likely called for. It was Louis van Tilborgh who, through literally piggy-backing on my efforts as a lowly grad student, built a somewhat shallow theorum of V(D)J transduriality sans any true bearing on II and III quartile cererbral throughput. Additionally, Nerr-Jenkins has had his credibility diminshed by his recent addition to the National Sex Offenders List and Hawley, I believe, was killed by a rabid elephant whilst on safari in Kenya.
Therefore, based upon your attribution chain the only true surviving – actually contributing figure remains that of Schechter. Personally and professionally, I feel his efforts remain lackluster and… quite plainly, Sir… he is a dick.
@ Thraxxus… I concur, the WHO population must be taken into consideration with any evolutionary comparative assay based upon sponges and people who shop at WalMart.
Perfect Specimen can be viewed at http://www.peopleofwalmart.com.
Brilliant work however this reminds me finding by Arnold Schonberg that I retrieved from the GOPHERNET written in 1951. Even though your conclusions are much more direct the work done Alfred Binet and your analysis of the RAG1 and RAG2 protein is without questions; I do feel it is worth mentioning that back in 1952 Antoine Lavoisier discovered that Guanine nucleotides when placed into a Hadron Collider produce provide evidence that Higgs boson particle does exist (allthough it is not clear where he got his sample). However when samples were taken from modern day specimens (from the genus homo, species sapiens) and the same test was performed the Higgs boson particle could not be observed. In contract when samples were taken from genus Mycobacteriaceae in the Actinobacteria genus. The partial was found in abundance. Which when paired with your research leads me to only one conclusion, the evolution of the sapiens species appears to be similar to the way that Double-stranded RNA monophyly uncertain reproduces and consumes. Furthermore without evidence of the Higgs boson particle in modern sapiens RAG1 Guanine nucleotides it would also seem that sapiens only gained dominance due to their ability to commit capital vices and not due to standard natural selection principles. It would seem that evolution in this case is similar to that of a antibiotic restraint strain of gonorrhea.
Fascinating.
Upon further investigation, I do recall taking note of this remarkable study from the early ’50s. So much so, in fact, that I randomly chose a dozen neighbors as unassuming participants for my brain tissue analysis (ethical considerations aside). And, to your point, there was ample evidence of Neisseria gonorrhoeae – or – common gonorrhea present in each sample extracted. I’d wanted to conduct further studies in this realm but my custom built high-enery particle accelerator burnt my scrotum so all subsequent efforts had to be cancelled.
FiveOClock offers a prime field study on this via his link above (for clarity, i’m refering to homo sapiens… not my scrotum).
definitely woke my brain up; but i got totally owned.
How ’bout them Lions!!! almsot football season